Grupo de Pesquisa em Biologia Experimental e Humana

Souza, L. G. de, Gaudio, M. S., Mariano, M. P. M., Oliveira, L. M. de, Madeira, A. B., Alves, G. L., Carlos, A. S., d’Avila, J. C. P., & Coelho, K. de O. (2025). Associação entre a homeostase glicêmica e transtornos mentais em pacientes diabéticos tipo 1. Revista De Medicina, 104(6), e-233196. https://doi.org/10.11606/issn.1679-9836.v104i6e-233196

Pisani RBF, Gonzalez VV, Witte BR, Gonçalves TG, Santiago LA, Moreno AM, Siqueira RA. Diabetic ketoacidosis knowledge in type 1 diabetes: a Brazilian perspective. Arch. Endocrinol. Metab. 2025;69(4):e250036. https://doi.org/10.20945/2359-4292-2025-0036

Estato V, Obadia N, Chateaubriand PH, Figueiredo V, Curty M, Costa Silva M, Ferreira RGL, Santa-Ritta J, Campos Baroni M, Aragão A, Neno JOG, Vasconcellos CAM, D’Avila JC, Gomes Granja M, Caire de Castro Faria-Neto H. Semaglutide restores astrocyte–vascular interactions and blood–brain barrier integrity in a model of diet-induced metabolic syndrome. Diabetol Metab Syndr 17, 2 (2025). https://doi.org/10.1186/s13098-024-01528-0

D’Avila J.C., Carlos AS, Vieira RL, Vergueiro C, Lima AT, Silva IDS, de Figueiredo VC, Chateaubriand PHP, Moreno AM, de Castro Faria Neto HC, Estato V, Siqueira RA. Beneficial effects of empagliflozin and liraglutide on the cerebral microcirculation of diabetic rats. Microcirculation. 2023;30:e12825. https://doi.org/10.1111/micc.12825

Silva, I., Souza, L., Pereira, P., Carvalho, J., Moreno, A., Castro-Faria-Neto, H., Siqueira, R.A., D’Avila, J., Carlos, A.S. Combination of a Glucagon-Like Peptide 1 Analog and a Sodium-Glucose Cotransporter 2 Inhibitor Improves Lipid Metabolism Compared to the Monotherapies in Experimental Metabolic Syndrome. Journal of Endocrinology and Metabolism, North America, 12, dec. 2022. Available at: https://www.jofem.org/index.php/jofem/article/view/843

Siqueira RA, Carlos AS, D’Avila JC, Moreno AM, Alves EL, Farias MLF, Mendonca LMC, Guimaraes MM.  Body Composition, But Not Insulin Resistance, influences postprandial lipemia in patients with Turner’s syndrome. Archives Of Endocrinology And Metabolism, 2021 May 18;64(6):758-763. doi: 10.20945/2359-3997000000287. (Artigo original)

Carlos AS, Souza LP, Siqueira RA, Moreno AM; D’Avila JC, Costa CAS, Santos AS, Lisboa PC, Nascimento-Saba CCA. Effects of high-fat diet on adipose tissue and pancreatic islet function in ovariectomized rats. International Journal Of Development Research, v. 9, p. 26348, 2019. (Artigo original)

Siqueira, R. A.; Alves, E. L.; Carlos As; D’Avila, J.C.; Moreno AM; SALLES, E. F.; GUIMARÃES. Estrogen route reposition does not affect postprandial lipemia and inflammation in patients with turner syndrome. International Journal Of Development Research, v. 09, p. 26531, 2019 (Artigo original)

Aragão De Araújo, Alice ; Moraes Silva, Janaína ; Alves Pereira, Tassiane Maria ; Moreira, Rayele ; Nunes, Monara ; Rocha, Kaline ; Silva Teixeira, Silmar ; Orsini, Marco ; Mafra Moreno, Adalgiza, Carlos, A.S. ; Ribeiro, Pedro ; Muller, Maria Izabel ; Roque De Souza, Giseli  Análise Da Potência Absoluta Na Banda Gama No Córtex Pré-Frontal Após Diagonal De Membro Superior. Revista De Neurociências, V. 26, P. 1-23, 2019.

Oliveira, Igor F. S. ; Neves, Hellen S. ; Franco, Myllena F. ; Carlos, Aluana S. ; Medeiros, Simoni M. ; Moreno, Adalgiza Mafra ; Araujo, Andressa Nunes ; Tenorio, Vitor . Assessment of the Hypoglycemic Effects of the Aqueous Extracts of Bauhinia Forficata in Wistar Rats Fed with a High Fat Diet. International Journal Of Biology, V. 10, P. 62, 2018 (Artigo original)

Oliveira, I. F. S. ; Tomiura, H. Y. ; Silva, B. C. F. ; Rodrigues, R. A. ; Medeiros, S. M. ; Moreno, A. M. ; Carlos, A. S. ; Tenorio, V. . Quality Control And Hypoglycemic Effect Evaluation Of Drugs With Bauhinia Forficata Link. (Fabaceae). International Journal Of Development Research, v. 08, p. journalijdr, 2018. (Artigo original)

Capítulo de livro: IMPACTO DO USO DE HIPOGLICEMIANTES NA SAÚDE MENTAL DE PACIENTES DIABÉTICOS. JP de Azevedo, KO Coelho, GP Correia, AS Carlos, J da Costa d’Avila. https://editora.editoraomnisscientia.com.br/artigoPDF/24220105594.pdf

Tavares, M. S., de Menezes, S. L. S., Rodrigues, C. T., Guimarães, T. T., Dias, L. A., de Moura, P. H., Magalhães, E. M. M., d’Avila, J. da C. P., & Moreno, A. M. (2024). A inserção social do idoso: reflexões sobre a inclusão, saúde e bem-estar. Cuadernos De Educación Y Desarrollo, 16(2), e3496. https://doi.org/10.55905/cuadv16n2-113

D’Avila J.C., Moreira El Nabbout T.G., Georges Moreira El Nabbout H., Silva A.S., Barbosa Ramos Junior A.C., Fonseca E.R., Carlos A.S., Siqueira R.A. Correlation between low handgrip strength and metabolic syndrome in older adults: a systematic review. Arch Endocrinol Metab. 2024 May 6;68:e230026. https://doi.org/10.20945/2359-4292-2023-0026

d’Avila JC, Ramos ACB, Dourado DRS, Siqueira RA,  Carlos AS, Moreno AM. Mecanismos moleculares do envelhecimento: revisão da literatura. RBCEH. Revista Brasileira De Ciências do Envelhecimento Humano, v. 17, p. 90-108, 2020. doi:10.5335/rbceh.v17i1.10543 (Artigo de revisão)

d’Avila JC. Neuroinflammation and oxidative stress in the aging brain: Linking in metabolism, stem cells, proteostasis, and stress adaptation. In: Colin R. Martin & Victor R. Preedy. (Org.). Oxidative Stress And Dietary Antioxidants In Neurological Diseases. 1ed.: Elsevier Academic Press, 2020, p. 49-65. doi: 10.1016/B978-0-12-817780-8.00004-9 (Capítulo de livro)

Oliveira MPL, Orsini M, Tuza FAD, De Moura PH, Da Siva ANM, Da Silva BV, Carlos AS, d’Avila JC, Moreno AM.  Estudo transversal da capacidade funcional e força muscular em setuagenários institucionalizados. Fisioterapia Brasil, v. 21, p. 182, 2020. doi:10.33233/fb.v21i2.4078 (Artigo original)

d’Avila JC, Siqueira LD, Mazeraud A, Azevedo EP, Foguel D, Castro-Faria-Neto HC, Sharshar T, Chrétien F, Bozza FA. Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation. Journal of Neuroinflammation. 2018 Jan 30;15(1):28. doi: 10.1186/s12974-018-1059-y. (Artigo original QUALIS A1)

Joana C. d’Avila. Chapter 4 – Neuroinflammation and oxidative stress in the aging brain: Linking in metabolism, stem cells, proteostasis, and stress adaptation. In: Oxidative Stress and Dietary Antioxidants in Neurological Diseases, 2020, Pages 49-65. https://doi.org/10.1016/B978-0-12-817780-8.00004-9

Alexandrino-Júnior, F.; Barcellos, G.; Gonçalves-Oliveira, L.F.; Côrtes, L.M.d.C.; Souza-Silva, F.; Alves, C.R.; Dias-Lopes, G.; Peixoto, J.F.; Patricio, B.F.d.C.; Rocha, H.V.A. Beyond the Skin: Topical Amphotericin B Nanocarriers Targeting Cutaneous Leishmaniasis with Suppression of Lymphatic Parasite Burden. Infect. Dis. Rep. 2026, 18, 6. https://doi.org/10.3390/idr18010006

Farshchi, F., Negahdary, M., Souza-Silva, F. et al. Emerging biosensor-based methodologies and strategies for leishmaniases: trends, technologies, and translational potential. Microchim Acta 193, 101 (2026). https://doi.org/10.1007/s00604-025-07732-7

Alcón-Chino, M.E.T.; Bonoldi, V.L.N.; Pereira, R.M.R.; Gazeta, G.S.; Carvalho, J.P.R.S.; Napoleão-Pêgo, P.; Durans, A.M.; Souza, A.L.A.; De-Simone, S.G. New Epitopes for the Serodiagnosis of Human Borreliosis. Microorganisms 2024, 12, 2212. https://doi.org/10.3390/microorganisms12112212

Moraes CA, Hottz ED, Dos Santos Ornellas D, Adesse D, de Azevedo CT, d’Avila JC, Zaverucha-do-Valle C, Maron-Gutierrez T, Barbosa HS, Bozza PT, Bozza FA. Microglial NLRP3 Inflammasome Induces Excitatory Synaptic Loss Through IL-1β-Enriched Microvesicle Release: Implications for Sepsis-Associated Encephalopathy. Mol Neurobiol. 2023 Feb;60(2):481-494. https://doi.org/10.1007/s12035-022-03067-z

Nicoletti CD, Dos Santos Galvão RM, de Sá Haddad Queiroz M, Barboclher L, Faria AFM, Teixeira GP, Souza ALA, de Carvalho da Silva F, Ferreira VF, da Silva Lima CH, Borba-Santos LP, Rozental S, Futuro DO, Faria RX. Inclusion complex of O-allyl-lawsone with 2-hydroxypropyl-β-cyclodextrin: Preparation, physical characterization, antiparasitic and antifungal activity. J Bioenerg Biomembr. 2023 Jun;55(3):233-248. https://doi.org/10.1007/s10863-023-09970-x

Ferreira AC, Sacramento CQ, Pereira-Dutra FS, Fintelman-Rodrigues N, Silva PP, Mattos M, de Freitas CS, Marttorelli A, de Melo GR, Campos MM, Azevedo-Quintanilha IG, Carlos AS, Emídio JV, Garcia CC, Bozza PT, Bozza FA and Souza TML (2023) Severe influenza infection is associated with inflammatory programmed cell death in infected macrophages. Front. Cell. Infect. Microbiol. 13:1067285. https://doi.org/10.3389/fcimb.2023.1067285

Chaves OA, Sacramento CQ, Ferreira AC, Mattos M, Fintelman-Rodrigues N, Temerozo JR, Vazquez L, Pinto DP, da Silveira GPE, da Fonseca LB, Pereira HM, Carlos AS, d’Avila JC, Viola JPB, Monteiro RQ, Bozza PT, Castro-Faria-Neto HC, Souza TML. Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo. Pharmaceuticals 2022, 15, 21. https://doi.org/10.3390/ph15010021

Souza, T.M.L., Pinho, V.D., Setim, C.F. et al. Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation. Nat Commun 14, 199 (2023). https://doi.org/10.1038/s41467-023-35928-z

Ferreira AC, Soares VC, Azevedo-Quintanilha IG, Dias SSG, Fintelman-Rodrigues N, Sacramento CQ, MattoS M, De Freitas CS, Temerozo JR, Teixeira LD, Hottz E, Barreto EA, Pão CRR, Palhinha L, Miranda M, Bou-Habib DC, Bozza, FA, Bozza, PT, Souza TM. SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes. Cell Death Discovery (On Line), v. 7, p. 43, 2021. Doi: 10.1038/s41420-021-00428-w (Artigo original QUALIS A1).

Moraes CA; Zaverucha-Do-Valle C; Fleurance R; Sharshar T; Bozza FA; D’Avila JC. Neuroinflammation in Sepsis: molecular pathways of microglia activation. Pharmaceuticals (Basel). 2021 May 1;14(5):416. doi: 10.3390/ph14050416 (Artigo de revisão QUALIS A1)

Sacramento CQ, Fintelman-Rodrigues N, Temerozo JRS, Dias AP, Silva SSG, Santos C, Ferreira AC, Mattos M, Pão CRR, Et al. Antiviral Activity Of The Anti-Hcv Drugs Daclatasvir And Sofosbuvir Against Sars-Cov-2, The Aetiological Agent Of Covid-19. Journal Of Antimicrobial Chemotherapy, V. 77, P. 1, 2021. (Artigo original QUALIS A1)

Gomes, L. I. M.; Ferreira, A. C. Avaliação Bibliográfica do Novo Coronavírus – Covid19 e a Toxicidade dos Tratamentos com os fármacos: Hidroxicloroquina, Cloroquina, Azitromicina e Ivermectina. Revista Eletrônica Saberes Múltiplos, V. 11, P. 3, 2021.

Dorea, S. R. F.; Ferreira, A. C. . Utilização da Fototerapia UVB Como Tratamento Alternativo de Segunda Linha para Controle da Dermatite Atópica Moderada e Grave. Revista Eletrônica Saberes Múltiplos, V. 11, P. 36, 2021.

Azevedo-Quintanilha IG, Medeiros-De-Moraes IM, Ferreira AC, Reis PA, Vieira-De-Abreu A et al. Haem Oxygenase Protects Against Thrombocytopaenia And Malaria-Associated Lung Injury. Malaria Journal, V. 19, P. 234, 2020. (Artigo original)

Filntelman N, Sacramento CQ, Lima CR, Silva FS, Ferreira A. C. et al. Atazanavir, Alone Or In Combination With Ritonavir, Inhibits Sars-Cov-2 Replication And Pro-Inflammatory Cytokine Production. Antimicrobial Agents And Chemotherapy, V. 65, P. 1, 2020. (Artigo original QUALIS A1)

Dias SSG; Soares VC, Ferreira AC, Sacramento CQ, Fintelman-Rodrigues N et al. Lipid Droplets Fuel Sars-Cov-2 Replication and Production of Inflammatory Mediators. Plos Pathogens, V. 16, P. E1009127, 2020. (Artigo original QUALIS A1)

Freitas CS, Higa LM, Sacramento CQ, Ferreira AC, Reis PA, Delvecchio RM, et al. ; Yellow Fever Virus Is Susceptible To Sofosbuvir Both In Vitro And In Vivo. Plos Neglected Tropical Diseases, V. 13, P. E0007072, 2019. (Artigo original QUALIS A1)

Azevedo-Quintanilha, Isaclaudia G. De ; Vieira-De-Abreu, Adriana ; Ferreira, André C. ; Reis, Patricia A. ; Silva, Tathiany I. ; Nascimento, Danielle De O. ; Campbell, Robert A. ; Estato, Vanessa ; Weyrich, Andrew S. ; Bozza, Patrícia T. ; Zimmerman, Guy A. ; Castro-Faria-Neto, Hugo C. . Integrin Αdβ2 Influences Cerebral Edema, Leukocyte Accumulation And Neurologic Outcomes In Experimental Severe Malaria. Plos One, V. 14, P. E0224610, 2019. (Artigo original QUALIS A1)

Freitas CS, Rocha MEN, Sacramento CQ, Marttorelli A, Ferreira AC, Rocha N, Oliveira AC, et al.  Agathisflavone, A Biflavonoid From Anacardium Occidentale L., Inhibits Influenza Virus’ Neuraminidase. Current Topics In Medicinal Chemistry, V. 20, P. 111-120, 2019.  (Artigo original)

Kurtz P, d’Avila JC, Prado D, Madeira C, Vargas-Lopes C, Panizzutti R, Azevedo LCP, Bozza FA. Cerebral Multimodal Monitoring in Sepsis. Shock 2019 Feb;51(2):228-234. doi: 10.1097/SHK.0000000000001138 (Artigo original)

Pereira Barbalho, Aline ; Barbosa Brandão, Luiza ; Marques Rechuan, Mariana ; Barreto Lysandro, Mayara Cristina ; Feital Montezzi, Nina ; Tavares Lima Trajano, Eduardo ; Mafra Moreno, Adalgiza;  Santana, Aluana Carlos ; Custódio, Eduardo Jorge ; Orsini, Marco . Síndrome De Guillain-Barré Associada À Gastroenterite Bacteriana. Revista De Neurociências, V. 26, P. 1-19, 2019.

Ferreira, P. C. R.; Silva-Santos, MK ; De Azevedo, TS ; Ferreira, A. C. . A Utilização do Lúdico no Aprendizado de Biologia Celular no 7º Ano do Ensino Fundamental. Revista Eletrônica Saberes Multiplos, V. 7, P. 218-233, 2018.

Ferreira, André C.; Reis, Patrícia A. ; De Freitas, Caroline S. ; Sacramento, Carolina Q. ; et al. Beyond Members Of The Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication. Antimicrobial Agents And Chemotherapy, V. 63, P. E01389-18, 2018. (Artigo original QUALIS A1)

Sacramento C, Melo GR, Gabrielle R, Freitas CS, Rocha NH, Natasha Hoelz, Lucas Villas Bôas Miranda M, Fintelman-Rodrigues N, Marttorelli A, Ferreira AC, et. al. The Clinically Approved Antiviral Drug Sofosbuvir Inhibits Zika Virus Replication. Scientific Reports, V. 7, P. 40920, 2017. (Artigo original QUALIS A1)

 Ferreira AC; Zaverucha-Do-Valle C; Reis PA, Barbosa-Lima G, Vieira YR, Mattos M, Silva PP, Sacramento C, Castro Faria Neto HC, Campanati L, Tanuri A, Brüning K, BozzaFA, Bozza PT, Souza TM. Sofosbuvir Protects Zika Virus-Infected Mice From Mortality, Preventing Short- And Long-Term Sequelae. Scientific Reports, V. 7, P. 9409, 2017. (Artigo original QUALIS A1)